7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
- Product Name
- 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
- CAS No.
- 62252-26-0
- Chemical Name
- 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
- Synonyms
- JLK6;JCP 251);JCP251 (JCP-251;GAMMA-SECRETASE INHIBITOR XI;7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN;7-Amino-4-chloro-3-methoxy-1H-2-benzopyran;7-Amino-4-chloro-3-methoxy-isochromen-1-one;7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one;1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-;JLK 6,Amyloid-β,β-amyloid peptide,JLK-6,Abeta,Inhibitor,JLK6,inhibit,APP,amyloid β
- CBNumber
- CB8741619
- Molecular Formula
- C10H8ClNO3
- Formula Weight
- 225.63
- MOL File
- 62252-26-0.mol
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Property
- Melting point:
- 115 °C
- Boiling point:
- 456.1±45.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO (Slightly)
- pka
- 1.95±0.20(Predicted)
- form
- Solid
- color
- Yellow to Beige
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 28712
- Product name
- JCP251
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 28712
- Product name
- JCP251
- Packaging
- 100mg
- Price
- $961
- Updated
- 2024/03/01
- Product number
- 28712
- Product name
- JCP251
- Packaging
- 50mg
- Price
- $543
- Updated
- 2024/03/01
- Product number
- 28712
- Product name
- JCP251
- Packaging
- 250mg
- Price
- $1802
- Updated
- 2024/03/01
- Product number
- 2677
- Product name
- JLK6
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $690
- Updated
- 2021/12/16
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Chemical Properties,Usage,Production
Uses
JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.
Definition
ChEBI: 7-amino-4-chloro-3-methoxy-2-benzopyran-1-one is a member of isocoumarins.
Biological Activity
Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .
References
[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.
[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511.